Monday 6th May 2019, 11:00am
The genetic propensity of animals to transmit diseases affects survival in populations during epidemics, study shows.
Survival in animal populations during an epidemic is partly determined by the genetic propensity of individual animals to transmit it to others, research shows.
It is well known that genetic differences in disease resistance affect mortality rates in populations during an epidemic.
A genetic study led by scientists at The Roslin Institute, in collaboration with researchers in Spain, found that mortality rates also depend on genetic differences in endurance – the propensity of a sick animal to survive infection, and infectivity – the propensity of an infected animal to transmit the disease to others.
This is the first time scientists provide evidence of genetic variation in infectivity of infected animals.
Scientists looked at how long it took for turbot to become infected and ill with or die of Scuticociliatosis after being exposed to infected fish. Scuticociliatosis is one of the most important diseases in marine aquaculture worldwide.
They have used novel experimental designs and statistical modelling to investigate whether differences in the genes determined endurance, infectivity and resistance of infected fish and demonstrated how this contributed to survival.
"This study is the first existing evidence that animals differ genetically not only in their resistance to disease, but also in their ability to transmit disease. Our infection model in fish shows that genetic variation in infectivity of infected animals, in addition to variation in resistance and endurance, affects survival in populations. These results have important implications for understanding and controlling epidemics."Professor Andrew Wilson, Principal Investigator, The Roslin Institute
The study is published in the journal “Scientific Reports” and has been funded by the EU FP7 Framework project Fishboost and the UK Government’s Biotechnology and Biological Sciences Research Council.
Source: The Roslin Institute