Wednesday 3rd June 2020, 5:00pm
New findings about viral regions in the DNA of chickens could aid productivity for smallholder farms in developing countries.
Disease could be better managed in smallholder flocks, thanks to key discoveries about parts of the genetic code of chickens derived from viruses.
The findings aid understanding of these elements of the genome, which are remnants of historical Avian Leukosis Virus subgroup E (ALVE) infections.
These viral sections of the genome can give rise to harmful molecules, which hamper birds’ growth and productivity, but their presence can also prevent related external viruses from causing infection. In smallholder flocks, their contribution to disease prevention may outweigh their impact on productivity, according to the research.
An international team of scientists led by the Roslin Institute searched for and analysed ALVEs in the genetic codes of more than 400 chickens from villages in Ethiopia, Nigeria and Iraq. A diverse mix of ALVE types was found across the range of birds, in the first such study to focus on non-commercial chickens. Scientists found 850 previously unseen ALVE types, trebling the number documented to date.
The study could pave the way for further research to understand the role of each ALVE in immunity against external viruses, and such insights could help manage breeding and improve the health of flocks in low- and middle-income countries.
The study, published in Genetics Selection Evolution, was funded by the Centre for Tropical Livestock Genetics and Health (CTLGH) through a Biotechnology and Biological Sciences Research Council (BBSRC) Impact Accelerator Award and involved researchers from the CTLGH, the International Livestock Research Institute, and partners in Africa and Iraq.
In a related study, researchers described the two ALVEs found in the standard reference genome for chickens – a dataset used by scientists for research. The ALVEs in the reference genome, taken from one undomesticated ancestor to modern chickens, do not reflect the diverse mix of ALVEs in the DNA of chickens today, researchers found. For example, one of the ALVEs in the reference dataset has not been seen in any other chicken, according to the study.
The reference sequence remains vital for the research community, however, its comparison to the genomes of modern and pre-domesticated chickens should be considered when undertaking research, scientists say.
"In commercial poultry operations, viral segments of the genome can raise the risk of poor health to chickens, but they could provide a benefit in small flocks, where their ability to prevent other viruses could be highly beneficial."
Dr Andrew Mason, Formerly of the Roslin Institute, now at the University of York"Better understanding of the negative or positive effects of these endogenous viruses may enable improved production of meat or eggs in small-scale farms, such as those of low-and middle-income countries."
Dr Jacqueline Smith, Roslin Institute and Centre for Tropical Livestock Genetics and HealthThe study, in the journal Poultry Science, was carried out by researchers led by the Roslin Institute with their commercial partner Hy-Line International from Iowa, US.
Source: The Roslin Institute
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The University of Edinburgh
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